A general description of the alcoholism project (The Collaborative Study on the Genetics
of Alcoholism,
COGA) can be found in: Alcohol Health & Research World,
Volume 19, No. 3, p.228-236. Related web site: NIAAA
Hesselbrock V., T. Foroud, H. Edenberg, J. I. Nurnberger Jr., T. Reich,
J. P. Rice (2001) Genetics and alcoholism: the COGA project. In
Alcohol
in Health and Disease, eds. D. P. Agarwal, H. K. Seitz, NY, Marcel
Decker.
Rice, J.P., N.L. Saccone, T. Foroud, H.J. Edenberg, J.I.
Nurnberger Jr., A. Goate, R.R. Crowe, V. Hesselbrock, M. Schuckit, B.
Porjesz, T. Reich, H. Begleiter (2003) Alcoholism: the USA
Collaborative Study on the Genetics of Alcoholism (COGA). Encyclopedia
of the Human Genome, Nature Publishing Group.
Bierut, LJ, NL Saccone, JP Rice, A Goate, T Foroud, HJ
Edenberg, L Almasy, PM Conneally, R Crowe, V Hesselbrock, T-K Li, JI
Nurnberger, Jr, B Porjesz, MA Schuckit, J Tischfield, H Begleiter, and
T Reich (2002) Defining alcohol-related phenotypes in humans: The
Collaborative Study on the Genetics of Alcoholism. Alcohol Res Health
26, 208-213.
Confirmation studies on a second
set of families ascertained using the same criteria: Foroud, T.,
H.J. Edenberg, A. Goate, J. Rice, L. Flury, D.L. Koller, L.J. Bierut,
P.M. Conneally, J.I. Nurnberger Jr., K.K. Bucholz, T.-K. Li, V.
Hesselbrock, R. Crowe, M. Schuckit, B. Porjesz, H. Begleiter, T. Reich
(2000) Alcoholism
susceptibility loci: confirmation studies in a replicate sample and
further mapping, Alcohol. Clin. Exp. Res. 24: 933-945.
Song, J., D. L. Koller, T. Foroud, K. Carr, J. Zhao, J. Rice, J.
I. Nurnberger Jr., H. Begleiter, B. Porjesz, T. L. Smith, M. A.
Schuckit, H. J. Edenberg (2003) Association of GABAA
receptors and alcohol dependence and the effects of genetic imprinting.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,
117B, 39-45
Dick DM, Edenberg HJ, Xuei X, Goate A, Kuperman S, Schuckit M, Crowe R, Smith TL, Porjesz B, Begleiter H, Foroud T. Association of GABRG3 With Alcohol Dependence. Alcohol Clin Exp Res. 2004 Jan;28(1):4-9.
Genome scan for an alcoholism-related phenotype derived from latent class analysis: Foroud,T., Bucholz,K.K., Edenberg,H.J., Goate,A., Neuman,R.J., Porjesz,B., Koller,D.L., Rice,J., Reich.T., Bierut,L.J., Cloninger,C.R., Nurnberger,J.I.Jr., Li,T.-K., Conneally,P.M., Tischfield,J.A., Crowe,R., Hesselbrock,V., Schuckit,M., Begleiter,H. (1998) Linkage of an alcoholism-related severity phenotype to chromosome 16. Alc. Clin. Exp. Res. 22, 2035-2042.
Maximum Drinks as an
alcoholism-related phenotype: Saccone, N.L., J. M. Kwon, J.
Corbett, A. Goate, N. Rochberg, H.J. Edenberg, T. Foroud, T.-K. Li, H.
Begleiter, T. Reich, J. P. Rice (2000) A
genome screen of maximum number of drinks as an alcoholism phenotype.
Am. J. Med. Genet. 96, 632-637.
Dick, D.M., J. Nurnberger, Jr., H.J. Edenberg, A. Goate, R. Crowe,
J. Rice, K.K. Bucholz, J. Kramer, M.A. Schuckit, T.L. Smith, B.
Porjesz, H. Begleiter,
V. Hesselbrock, T. Foroud (2002) Suggestive
Linkage on Chromosome 1 for a Quantitative Alcohol-Related Phenotype.
Alc. Clin. Exp. Res. 26, 1453-1460.
Genome scan for a combined phenotype: alcoholism or depression: J. I. Nurnberger Jr., T. Foroud, L. Flury, J. Su, E. T. Meyer, K. Hu, R. Crowe, H. Edenberg, A. Goate, L. Bierut, T. Reich, M. Schuckit, W. Reich (2001) Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am. J. Psych. 158, 718-724.
Genome scan for Event-related brain potential (ERP): Begleiter,H., B.Porjesz, T.Reich, H.J.Edenberg, A.Goate, J.Blangero, L.Almasy, T.Foroud, P.VanEerdewegh, J.Polich, J.Rohrbaugh, S.Kuperman, L.O.Bauer, S.J.O’Conner, D.Chorlian, T.-K.Li, P.M.Conneally, V.Hesselbrock, J.P.Rice, M.A.Schuckit, R.Cloninger, J.I.Nurnberger Jr., R.Crowe, F.E.Bloom (1998) Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. Electroencephalogr Clin Neurophysiol. 108: 244-250.
Event-related brain potentials:
Almasy, L. B. Porjesz, J. Blangero, A. Goate, H.J. Edenberg, D.B.
Chorlian,
S. Kuperman, S.J. O’Connor, J. Rohrbaugh, L.O. Bauer, T. Foroud, J.P.
Rice,
T. Reich, H. Begleiter (2001) Genetics
of event-related brain potentials in response to a semantic priming
paradigm in families with a history of alcoholism. Am. J.
Human Genet.
68, 128-135.
Porjesz, B., H. Begleiter, K. Wang, L. Almasy, D.B. Chorlian, A.T.
Stimus, S. Kuperman, S.J. O’Connor, J. Rohrbaugh, L.O. Bauer, H.J.
Edenberg, A. Goate, J.P. Rice, T. Reich (2002) Linkage
and linkage disequilibrium mapping of ERP and EEG phenotypes.
Biological
Psychology 61, 229-248.
Porjesz, B., L. Almasy, H. J. Edenberg, K. Wang, D. B. Chorlian,
T.
Foroud, A. Goate, J. P. Rice, S. J. O’Connor, J. Rohrbaugh, S.
Kuperman,
L. O. Bauer,R. R. Crowe, M. A. Schuckit, V. Hesselbrock, P. M.
Conneally,
J. A. Tischfield, T.-K. Li, T. Reich, and H. Begleiter (2002) Linkage
disequilibrium between the beta frequency of the human EEG and a GABAA
receptor
gene locus. Proc. Natl. Acad. Sci. USA 99, 3729–3733.
Ghosh, S, H. Begleiter, B. Porjesz, D. B. Chorlian, H. J.
Edenberg, T. Foroud, A Goate, and T. Reich. (2003) Linkage Mapping of
Beta 2 EEG Waves via Non-Parametric Regression. Am. J. Med. Genet.
118B, 66–71.
Jones KA, Porjesz B, Almasy L, Bierut L, Goate A, Hinrichs A, Kwon
J, Rice JP, Rohrbaugh J, Stock H, Wang JC, Wu W, Bauer LO, Chorlian DB,
Dick DM, Edenberg HJ, Foroud T, Hesselbrock V, Kuperman S, Nurnberger
JJr, O’Connor SJ, Schuckit MA, Stimus AT, Reich T, Begleiter H. (2004)
Linkage and linkage disequilibrium of evoked EEG oscillations with
CHRM2 receptor gene polymorphisms: implications for human brain
dynamics and cognition. Int J Psychophysiol, 53, 75-90.
Background on Event-related brain potentials: Porjesz,B., H.Begleiter, T.Reich, P.VanEerdewegh, H.J.Edenberg, T.Foroud, A.Goate, A.Litke, D.Chorlian, A.Stimus, J.Rice, J.Blangero, L.Almasy, J.Sorbell, L.O.Bauer, S.Kuperman, S.J.O’Conner, J.Rohrbaugh. (1998) Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA project. Alcoholism: Clin. Exp. Res. 22, 1317-1323.
Application of new analytical technique, Bivariate analysis: Alcoholism and P300: Williams J.T., Begleiter H., Porjesz B., Edenberg H.J., Foroud T., Reich T., Goate A., Van Eerdewegh P., Almasy L., Blangero J. (1999) Joint Multipoint Linkage Analysis of Multivariate Qualitative and Quantitative Traits. II. Alcoholism and Event-Related Potentials. Am. J. Hum. Genet. 65: 1148-1160.
Genome scan for sensitivity to alcohol: Schuckit,
M.A., H. J. Edenberg, J. Kalmijn, L. Flury, T. L. Smith, T. Reich, L.
Bierut, A. Goate, T. Foroud (2001) A
genome-wide search for genes relating to a low level of response to
alcohol. Alcoholism: Clin. Exp. Res. 25, 323-329.
Bierut LJ, Rice JP, Goate A, Hinrichs AL, Saccone NL, Foroud T,
Edenberg HJ, Cloninger CR, Begleiter H, Conneally PM, Crowe RR,
Hesselbrock V, Li TK, Nurnberger JI Jr, Porjesz B, Schuckit MA, Reich
T. (2004) A genomic scan for habitual smoking in families of
alcoholics: Common and specific genetic factors in substance
dependence. Am J Med Genet. 124A(1): 19-27.
Dick DM, Li TK, Edenberg HJ, Hesselbrock V, Kramer J, Kuperman S,
Porjesz B, Bucholz K, Goate A, Nurnberger J, Foroud T. (2004) A
genome-wide screen for genes influencing conduct disorder. Mol
Psychiatry 9(1):81-6.
Genome scan for Personality Traits: Cloninger, C.R., P.Van Eerdwegh, A. Goate, H.J. Edenberg, J. Blangero, V. Hesselbrock, T. Reich, J.I. Nurnberger Jr., M.A. Schuckit, B. Porjesz, R. Crowe, J.P. Rice, T. Foroud, T. R. Przybeck, L. Almasy, K. Bucholz, W. Wu, S. Shears, K. Carr, C. Crose, C. Willig, J. Zhao, J.A. Tischfield, T.-K. Li, P.M. Conneally, H. Begleiter (1998) Anxiety proneness linked to epistatic loci in genome scan of human personality traits. Am.J.Medical Genet. 81, 313-317.
Introduction to GAW analysis of COGA data: The Genetic
Analysis Workshop was given the initial COGA genomic screen with data
on many phenotypes, to test analytical methods for localizing genes in
complex disorders. The results were published in Genet Epidemiol. 17
Suppl 1. Introduction:
Begleiter H, Reich T, Nurnberger J Jr, Li TK, Conneally PM, Edenberg H,
Crowe R, Kuperman S, Schuckit M, Bloom F, Hesselbrock V, Porjesz B,
Cloninger CR, Rice J, Goate A. (1999) Description
of the Genetic Analysis Workshop 11 Collaborative Study on the Genetics
of Alcoholism. Genet Epidemiol. 17 Suppl 1: S25-30.
DRD2 and smoking: Bierut LJ, Rice J, Edenberg HJ, Goate A,
Foroud T, Cloninger CR, Begleiter H, Conneally PM, Crowe RR,
Hesselbrock V, Li T-K, Nurnberger JIJr, Porjesz B, Schuckit MA and
Reich T (2000) A family-based study of the association of the dopamine
D2 receptor gene (DRD2) with habitual smoking. Am. J. Med. Genet. 90,
299-302.
HTT and Alcoholism: Edenberg, H.J., J. Reynolds, D.L. Koller, H. Begleiter, K.K. Bucholz, P.M. Conneally, R. Crowe, A. Goate, V. Hesselbrock, T.-K. Li, J.I. Nurnberger, B. Porjesz, T. Reich, J.P. Rice, M. Schuckit, J.A. Tischfield, T. Foroud (1998) A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence. Alcoholism: Clin. Exp. Res. 22, 1080-1085.
Technique for detecting HTT polymorphism: Edenberg, H.J. and J. Reynolds (1998) Improved method for detecting the long and short promoter alleles of the serotonin transporter gene HTT (SLC6A4). Psychiatric Genetics 8, 193-195.
MAO activity: Saccone, N.L.,
J.P. Rice, N. Rochberg, A. Goate, T. Reich, S. Shears, W. Wu, J.I.
Nurnberger, Jr., T. Foroud, H.J. Edenberg, T.-K. Li (1999) A
genome screen for platelet monoamine oxidase (MAO) activity. Am.
J. Med. Genet. (Neuropsychiatric Genetics) 88: 517-521.
Saccone, N.L., J.P. Rice, N. Rochberg, J.T. Williams, A. Goate, T.
Reich, H.J. Edenberg, T. Foroud, J.I. Nurnberger Jr., L.J. Bierut, R.
Crowe, T.-K. Li (2002) Linkage
for platelet monoamine oxidase (MAO) activity: results from a
replication
sample. Alcohol. Clin. Exp. Res. 26, 603-609.
DRD2 and Smoking:
Bierut
LJ, Rice J, Edenberg HJ, Goate A, Foroud T, Cloninger CR, Begleiter H,
Conneally PM, Crowe RR, Hesselbrock V, Li T-K, Nurnberger JIJr, Porjesz
B, Schuckit MA and Reich T (2000) A
family-based study of the association of the dopamine D2 receptor gene
(DRD2) with habitual smoking. Am. J. Med. Genet. 90,
299-302.