Howard J. Edenberg, Ph.D., Director
Chancellor's Professor
Professor of Biochemistry and Molecular Biology and
of Medical and Molecular Genetics
Indiana University School of Medicine
Indianapolis, Indiana 46202-5122

Mission:

The long-term goal of the Center for Medical Genomics at the Indiana University School of Medicine is to improve health by facilitating cutting-edge research with state-of-the-art genomic technologies for studying gene expression and genetics. Advances in the human genome project provide the foundation for a new way of studying health and disease, in which differences in the sequence and expression of thousands of genes can be analyzed. The Center for Medical Genomics provides infrastructure and consulting for use of genomic technology in studies of disease and in other biomedical research. We will pursue further development of these technologies, and assist investigators in their use.

• Microarrays : Experiments using microarray technology will provide clues to diagnoses and prognoses of diseases, treatment choices, drug design, and fundamental understanding of biology.

• High-throughput Genotyping : Genes influence all of our physiological and pathological processes. Individual differences in gene sequence lead to differences in the risk for diseases and in the response to treatment. Experiments using high-throughput genotyping will enable us to study how genes influence disease and treatment in large populations.

These genomic technologies allow us to explore gene expression and genetic differences, and will impact virtually all areas of biomedical and biological research, diagnosis and treatment in dramatic ways. Studies based on these genomic approaches will lead to better diagnosis of diseases, better treatments (including more effective drugs with fewer side-effects) and cures. Medicine will move into an era of more individualized treatments.

photo of Affymetrix Fluidics station in use

Services

• Affymetrix GeneChips®

• Custom-made spotted arrays

• High-throughput genotyping

• Note: users should acknowledge the Center for Medical Genomics in publications resulting from work carried out by the Center: "The microarray studies were carried out using the facilities of the Center for Medical Genomics at Indiana University School of Medicine. The Center for Medical Genomics is supported in part by the Indiana Genomics Initiative at Indiana University (INGEN®, which is supported in part by the Lilly Endowment, Inc.)."

• Please send copies of manuscripts that include CMG data to Dr. Edenberg; please also keep him informed of the status of grants for which letters of support have been provided.

The Center for Medical Genomics was founded with support from a competitive, peer-reviewed grant from the State of Indiana 21st Century Research and Technology Fund. Additional support is from the Indiana Genomics Initiative , funded by a generous grant from the Lilly Endowment, Inc. and from the Indiana University School of Medicine.